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Level of evidence Design Treatment and dose Patient-reported outcome Reference Control over ejaculation Satisfaction with intercourse Personal distress related to ejaculation Interpersonal difficulty related to ejaculation CGI of change in PE 1 Integrated analysis of five studies DPX 30 mg or 60 mg, or PBO Improvement over placebo for both doses of DPX both P Improvement over placebo for both doses of DPX both P Improvement over placebo for both doses of DPX both P Improvement over placebo for both doses of DPX both P Improvement over placebo for both doses of DPX both P McMahon et al45 1 Integrated analysis of two studies DPX 30 mg or 60 mg, or PBO Improvement over placebo for both doses of DPX both P Improvement over placebo for both doses of DPX both P NR NR Improvement over placebo for both doses of DPX both P Pryor et al46 1 Integrated analysis of two studies DPX 30 mg or 60 mg, or PBO Improvement over placebo for both doses of DPX both P Similar results for acquired lifelong PE Improvement over placebo for both doses of DPX both P Similar results for acquired lifelong PE Improvement over placebo for both doses of DPX both P Similar results for acquired lifelong PE Improvement over placebo for both doses of DPX both P Similar results for acquired lifelong PE NR Porst et al47 2 Double-blind RCT, 12 weeks, n 1067 DPX 30 mg or 60 mg, or PBO patients rating control good or very good DPX 30 33 buy cialis canada pharmacy 42 hours, and a terminal half-life of 18